optical spectroscopic technique is called partial waves (PSC) microscopy and developed by Vadim Backman, who was a professor of biomedical engineering at the School of Engineering and Applied Science McCormick Northwestern. Before using the PSC and Roy Backman to assess the risk of colon cancer and pancreatic cancer with promising results, too.
The discovery of lung cancer was made public via the Internet on October 5, yesterday in the journal Cancer Research. His paper to print on October 15 edition.
Lung cancer is the leading cause of cancer deaths in the United States. The survival rate to be raised to the surgical resection (tumor removal), but only if detected at an early stage. Currently, there are no tests that suggested to the community to detect lung cancer early. The disease is already at the highest when most patients have symptoms of lung cancer. A rate of five-year survival for patients with lung cancer only 15 percent.
"Effects of field 'test harness based on the PMF, which is a biological phenomenon, where the cells located at a distance of malignancy or pre-malignant changes in molecular and others.
"Besides the fact that these cells appear normal with the standard microscope that describe the architecture of cells at a micro level, in fact there are major changes in the architecture of these cells at the nanoscale." Said M . Backman. Measurement of disturbance power "of the PSC nanoscale organization that we have the cell to one of the first signs of karsinogenesis and is a strong marker of the presence of cancer in the organs of the body."
"The MFP is a paradigm shift in this case we do not need to be considered in determining the existence of a cancer tumor," says Hariharan Subramanian a peer researchers in the laboratory that Backman has played an important role in the development of technology.
After testing the technology on a small scale experiments, Roy and purpose of the study on smokers Backman, because smoking is the main risk factor associated with 90 percent of patients with lung cancer. "The idea is basically that smoking not only affects the lungs, but the overall channel breath," said Roy.
The study included 134 participants, including 63 groups suffering from lung cancer of smokers and 37 smokers who suffer from chronic obstructive pulmonary disease (PPOK), 13 smokers not exposed PPOK and the Group of 22 non-smoking. This research is not mixed with demographic factors such as level of smoking, age or sex. The average major test is sensitive to cancer at all stages including early cancer can be cured.
The researchers wiped the inside of the patient's mouth and cheek cells then are placed in a glass microscope, fixed with ethanol and then scanned with the PSC to measure the strength of the architecture of nano cell disruption. Result real increase (over 50 percent) in patients suffering from lung cancer than smokers who do not have cancer.
Further evaluation of the characteristics of performance characteristics - "the power of these disorders" (biological impact marker) showed more than 80 percent accuracy in distinguishing patients with cancer patients in the third group.
"The result is similar to successful cancer screening techniques, such as Pap smear" said Backman. "Our goal is to develop a technique that can improve cancer detection of cancer in the other to provide early treatment as well as the Pap smear, which significantly improves the survival rate of cancer patients servik."
PSC requires validation tests on a large scale. If the PSC is proven effective in clinical trials for early detection of cancer, and Roy Backman was convinced that the PSC can potentially be used as a euphemism screening that identifies high-risk patients who may require a more thorough test such as bronchoscopy or CT scan.
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